The dropping of keys is quite rare, sometimes dropping only one in 10-15 runs. They need to be killed in a Hell difficulty game in which they have a chance to drop the Keys of Hate, Terror and Destruction respectively along with their normal drop. To get the keys, the player has to kill one of the agents of the Prime Evils on the mortal plane. This means that the player will have to collect, in all, three keys of each type, which totals to nine keys. There are three different keys, and to open any one of the minor portals, a complete set of three different keys are required.

The Keys are required to open the three portals that will help you collect the Organs. Nine total keys, three of each type, are thus the minimum required to access Chaos Tristam.

These Organs, in turn, each require the collection of three Keys to open a portal which itself contains one Organ. The initiation of the quest involves the collection of the three separate Organs that will open the portal to Chaos Tristram when transmuted in the Horadric Cube. Diablo II: Resurrected Review - Pile Of Old BonesĢ9 September 2021 The Keys and Organs

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